GA@net Entry
Goethe University Frankfurt / Institute of Pharmaceutical Biology
Organization
Address
Max-von-Laue-Str. 9
Zip/Post Code
60438
City
Frankfurt
Country
Germany
Personal data
Main Area of Expertise
Areas
NP Pharmacol., bioassays, mode of act
... please specify
Molecular pharmacology of natural products in the areas of inflammation and angiogenesis with a special focus on vascular endothelial cells; functional, phenotypic screening, mode of action, molecular mechanisms, signaling
Main output/products/publications
• Stark A, …, Fürst R. Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and downregulation of the endothelial TNF receptor 1. FASEB J. 2019; 33: 8771-8781.
• Fuchs S, …, Fürst R. Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. J Cell Mol Med. 2015; 19: 1021-1032.
• Kretzschmann VK, …, Fürst R. The novel tubulin antagonist pretubulysin displays anti-vascular properties in vitro an in vivo. Arterioscler Thromb Vasc Biol. 2014; 34: 294-303.
• Berberich N, …, Fürst R. Roscovitine attenuates leukocyte-endothelial cell interaction by inhibiting endothelial activation via blocking cyclin-dependent kinase 5 and 9. Br J Pharmacol. 2011; 163: 1086-1098
• Schmerwitz UK, …, Fürst R. Flavopiridol protects against inflammation by attenuating leukocyte-endothelial cell interaction via inhibition of CDK9. Arterioscler Thromb Vasc Biol. 2011; 31: 280-288
Fields of interest
