Althanstrasse 14

Wien

Österreich

Univ-Prof. Dr. Judith M. Rollinger

0000-0001-6581-0774

• Search for drug leads from nature using chemoinformatics and biochemometry with special emphasis on candidates against viral infections (SARS COV2, Influenza), inflammation and metabolic syndrome. • Discovery of bioactive compounds from untapped sources and traditional medicine using big data analysis for the targeted identification and isolation of bioactive constituents. • Phenotypic screening using C. elegans (life/health span, fat accumulation, neurodegeneration) • Analysis, isolation and structure elucidation of secondary metabolites from different resources (plants, lichens, microbes, fungi) • SFx-green technology for extraction, analysis and isolation of natural products

• Zwirchmayr J, Kirchweger B, Lehner T, Tahir A, Pretsch D, Rollinger JM. A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans. Scientific Rep 2020, 10:12323, doi.org/10.1038/s41598-020-69186-6 • Zwirchmayr J, Grienke U, Hummelbrunner S, Seigner J, de Martin R, Dirsch VM, Rollinger JM. A Biochemometric Approach for the Identification of In Vitro Anti-Inflammatory Constituents in Masterwort. Biomolecules 2020 , 10: 679; doi.org/10.3390/biom10050679 • Kirchweger B, Rollinger JM. A Strength-Weaknesses-Opportunities-Threats (SWOT) Analysis of Cheminformatics in Natural Product Research. Prog Chem Org Nat Prod. 2019; 110:239-271. DOI: 10.1007/978-3-030-14632-0_7 • Kratz JM, Grienke U, Scheel O, Mann SA, Rollinger JM. Natural products modulating the hERG channel: heartaches and hope. Nat. Prod. Rep., 34, 2017, 957-980. DOI: 10.1039/c7np00014f • Grienke, U.; Richter, M.; Walther, E.; Hoffmann, A.; Kirchmair, J.; Makarov, V.; Nietzsche, S.; Schmidtke, M.; Rollinger, JM. Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae. Sci. Rep. 6, 27156, 2016. DOI: 10.1038/srep27156