BioTransform
DC8 Open Position: In vitro microsomal metabolism of dialysates produced in the GIDM-Colon and activity of metabolites
Job description
DC8: In vitro microsomal metabolism of dialysates produced in the GIDM-Colon and activity of metabolites
Host institution: Riga Stradins University (RSU), Latvia
Supervisor: Prof. Maija Dambrova
Co-Supervisors: Prof. Nina Hermans, Natural Products & Food Research and Analysis – Pharmaceutical Technology (NatuRAPT), University of Antwerp, Belgium (Academic); Dr. Job Tchoumtchoua, CELABOR, Herve, Belgium (Industrial)
Project description:
BioTransform is a multidisciplinary doctoral network aiming to investigate the role of health-promoting constituents found in food products (food bioactives – FB), focusing on their metabolism. FB coexist with nutrients, but they are biologically active compounds present in our diet and characterised by great structural variability and biological properties. Despite the imperative role of gut microbiota in health maintenance and disease prevention, the available information regarding FB metabolism remains scarce, and the biotransformation occurring in the human organism is highly unexplored. Thus, the goal of BioTransform is to combine state-of-the-art methods, technologies, and approaches in a complementary and integrated way to reveal the impact of FB and their metabolites (biotransformation products) on health and disease. To this end, human pilot studies, in vitro and in silico metabolism simulation methods, gut microbiota sequencing, metabolite profiling, and metabolomics will be employed. Metabolites will be biologically profiled through biochemical and cell-based assays. In BioTransform, the metabolism of olive and bilberry FB (secoiridoids, phenols, and polyphenols), which are European flagship food products with proven activity in metabolism-related pathologies, will be systematically investigated.
The application window will be open from 1/2/2026 until 31/3/2026. The expected starting date is 1/7/2026.
BioTransform
DC9 Open Position: Exploration of olive and bilberry bioactives bioavalability aspects through advanced in silico techniques
Job description
DC9: Exploration of olive and bilberry bioactives bioavalability aspects through advanced in silico techniques
Host institution: Department of Life Sciences, University of Bath (UBath), United Kingdom
Supervisor: Prof. Nikoletta Fotaki
Co-Supervisors: Prof. Nikolaos Tentolouris, Medical School, Laiko General Hospital, National and Kapodistrian University of Athens (NKUA), Greece (Academic); Dr. Olaf Kelber, Steigerwald Arzneimittelwerk, Darmstadt, Germany (Industrial)
Project description:
BioTransform is a multidisciplinary doctoral network aiming to investigate the role of health-promoting constituents found in food products (food bioactives – FB), focusing on their metabolism. FB coexist with nutrients, but they are biologically active compounds present in our diet and characterised by great structural variability and biological properties. Despite the imperative role of gut microbiota in health maintenance and disease prevention, the available information regarding FB metabolism remains scarce, and the biotransformation occurring in the human organism is highly unexplored. Thus, the goal of BioTransform is to combine state-of-the-art methods, technologies, and approaches in a complementary and integrated way to reveal the impact of FB and their metabolites (biotransformation products) on health and disease. To this end, human pilot studies, in vitro and in silico metabolism simulation methods, gut microbiota sequencing, metabolite profiling, and metabolomics will be employed. Metabolites will be biologically profiled through biochemical and cell-based assays. In BioTransform, the metabolism of olive and bilberry FB (secoiridoids, phenols, and polyphenols), which are European flagship food products with proven activity in metabolism-related pathologies, will be systematically investigated.
The application window will be open from 1/2/2026 until 31/3/2026. The expected starting date is 1/7/2026.
BioTransform
DC10 Open Position: Correlation studies between spectrometric, spectroscopic, biochemical, and microbiome sequencing data after intake of bilberry and olive bioactives
Job description
DC10: Correlation studies between spectrometric, spectroscopic, biochemical, and microbiome sequencing data after intake of bilberry and olive bioactives
Host institution: Department of Metabolism, Digestion and Reproduction, Imperial College London (ICL), United Kingdom
Supervisor: Dr. Isabel Garcia-Perez, Dr. Joram M. Posma
Co-Supervisors: Prof. Maija Dambrova, Pharmaceutical Chemistry, Riga Stradins University (RSU), Latvia (Academic); Dr. Rene Roth-Ohrang, Finzelberg, Andernach, Germany (Industrial)
Project description:
BioTransform is a multidisciplinary doctoral network aiming to investigate the role of health promoting constituents found in food products (food bioactives – FB), focusing on their metabolism. FB coexist with nutrients, but they are biologically active compounds present in our diet and characterised by great structural variability and biological properties. Despite the imperative role of gut microbiota in health maintenance and disease prevention, the available information regarding FB metabolism remains scarce and the biotransformation occurring in the human organism highly unexplored. Thus, the goal of BioTransform is to combine state-of-the-art methods, technologies and approaches in a complementary and integrated way to reveal the impact of FB and their metabolites (biotransformation products) on health and disease. To this end, human pilot studies, in vitro and in silico metabolism simulation methods, gut microbiota sequencing, metabolite profiling and metabolomics will be employed. Metabolites will be biologically profiled through biochemical and cell-based assays. In BioTransform, the metabolism of olive and bilberry FB (secoiridoids, phenols and polyphenols), which are European flagship food products with proven activity in metabolism-related pathologies, will be systematically investigated.
The application window will be open from 1/2/2026 until 31/3/2026. The expected starting date is 1/7/2026.
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