GA@net Entry
Medical Univeristy of Lublin; Independent Laboratory of Natural Products Chemistry
Organization
Address
Chodzki 1
Zip/Post Code
20-093
City
Lublin
Country
Poland
Personal data
Contact person
Prof. Krystyna Skalicka-Woźniak
Phone
ORCID-ID
0000-0002-9313-5929
Role in Organization
Main Area of Expertise
Areas
... please specify
The focus of the group is the application of counter-current chromatography (CCC) for the isolation of natural products, particularly coumarins and terpenoids, and their biological evaluation for antimicrobial, antiviral, anticancer, spasmolytic, apoptotic, and antioxidant activities, as well as for Central Nervous System activity (epilepsy, anxiety and memory-related behavior – in vitro and in vivo with mice and zebrafish models).
Main output/products/publications
Krystyna Skalicka-Woźniak, Ian Garrard. A comprehensive classification of solvent systems used for natural product purifications in countercurrent and centrifugal partition chromatography. Nat. Prod. Rep., 2015,32, 1556-1561
Krystyna Skalicka-Woznia , Barbara Budzynska*, Grazyna Biala, and Anna Boguszewska-Czubara. Scopolamine-Induced Memory Impairment Is Alleviated by Xanthotoxin: Role of Acetylcholinesterase and Oxidative Stress Processes. ACS Chem. Neurosci. 2018, 9, 5, 1184–1194
Krystyna Skalicka-Woźniak, Magdalena Walasek, Tariq M Aljarba, Paul Stapleton, Simon Gibbons, Jianbo Xiao, Jarogniew J Łuszczki. The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study. Food and Chemical Toxicology, 2018, 120, 472-478
Ewelina Kozioł, Fatma Sezer Senol, Deniz, Ilkay Erdogan Orhan, Laurence Marcourt, BarbaraBudzyńska, Jean-Luc Wolfender, Alexander Crawford, Krystyna Skalicka-Woźniak. High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae). Phytomedicine, 2019, 54, 259-264
Atanas G Atanasov, , Sergey B Zotchev, Verena M Dirsch, International Natural Product Sciences Taskforce; Claudiu T Supuran. Natural products in drug discovery: advances and opportunities . Nature Reviews Drug Discovery, 2021, 20, 200–216.
Fields of interest